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. 2021 Oct 25;11:20979. doi: 10.1038/s41598-021-00494-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Protein–protein interactions network produced by NetworkAnalyst 3.0. Significant factors (seeds) are highlighted with a blue circle. The size of the nodes is based on their degree (connectivity) values, with a big size for large degree values. The color of the nodes is proportional to their betweenness centrality values, starting from red for higher values.