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. 2021 Oct 26;7:99. doi: 10.1038/s41421-021-00329-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Clinical laboratory routine tests include hematologic and coagulation parameters, blood glucose-related and infection-related indices, lipid profile, cardiac enzymes, electrolytes, liver- and renal function-related biomarkers. More information could be found in Supplementary Tables S4 and S5. Laboratory test values of white blood cell count (b), HbA1c (c), potassium (d, left panel), sodium (d, right panel), APTT (e, left panel), PT (e, right panel), total cholesterol (f), total bile acid (g), eGFR (h, left panel), creatinine (h, right panel). Data points represent the values of each individual. Box plots showed the 25th, 50th (median), and 75th percentiles. Horizontal dashed lines showed upper normal limits (red) in b, c, d (left panels), e (left panel), f, h and the lower normal limits (blue) in d (left panel) and h. The P values were calculated by the Wilcoxon sign-rank test by comparing the laboratory measurements at each time with the baseline measurements. *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001.