TABLE 4.
The correlation of HSPs mutations with expression and prognosis in pan-cancer.
| Gene | Mutation and expression | Mutation and prognosis | CancerType | ||
|---|---|---|---|---|---|
| Differential | p Value | HR 95% (CI) | p Value | ||
| HSP90AA1 | up-regulated | 0.020 | 0.43 (0.17–1.09) | 0.218 | UCEC |
| HSPA4L | up-regulated | 0.001 | 0.31 (0.14–0.71) | 0.085 | UCEC |
| HSPA9 | up-regulated | 0.043 | 0.30 (0.12–0.68) | 0.075 | UCEC |
| HSPA8 | up-regulated | 0.030 | 0.16 (0.07–0.37) | 0.036 | UCEC |
| HSPH1 | up-regulated | 0.006 | 0.20 (0.10–0.40) | 0.013 | UCEC |
| TRAP1 | up-regulated | 0.003 | 0 | 0.017 | UCEC |
| HSPA1A | down-regulated | 0.006 | 1.21 (0.46–3.22) | 0.668 | STAD |
| HSPA1L | down-regulated | 0.008 | 1.48 (0.63–3.45) | 0.279 | STAD |
| HSPA2 | down-regulated | 0.007 | 1.61 (0.63–4.15) | 0.210 | STAD |
| TRAP1 | up-regulated | 0.031 | 0.84 (0.37–1.92) | 0.708 | STAD |
| HSPA12A | down-regulated | 0.030 | 0.71 (0.14–3.76) | 0.733 | BRCA |
| HSPA8 | up-regulated | 0.007 | 0 | 0.386 | CESC |
| HSPA6 | up-regulated | 0.022 | 1.02 (0.32–3.27) | 0.970 | COAD |
| HSPA9 | down-regulated | 0.038 | 0.79 (0.28–2.22) | 0.685 | COAD |
| HSPH1 | down-regulated | 0.047 | 0.84 (0.14–5.18) | 0.866 | COAD |
| HSPA2 | down-regulated | 0.022 | 0.88 (0.23–3.27) | 0.851 | ESCA |
| HSPA13 | down-regulated | 0.028 | 0 | 0.772 | KIRP |
| HSP90AB1 | up-regulated | 0.043 | 0.95 (0.14–6.50) | 0.961 | LIHC |
| HSPA1L | up-regulated | 0.012 | 2.60 (0.42–15.99) | 0.090 | LIHC |
| HSPA12A | down-regulated | <0.001 | 2.29 (0.68–7.66) | 0.040 | LUAD |
| HSPA8 | up-regulated | 0.018 | 1.55 (0.46–5.29) | 0.380 | LUAD |
| HSPA14 | down-regulated | 0.035 | 0 | 0.112 | LUSC |
| HSPA5 | up-regulated | 0.019 | 1.98 (0.28–13.86) | 0.330 | PAAD |
| HSP90AB1 | up-regulated | 0.041 | 1.78 (0.39–8.07) | 0.318 | SARC |
| HSPA14 | up-regulated | 0.002 | 1.54 ().38–6.29) | 0.453 | SKCM |