Table 3.
Cluster analysis of KEGG pathways, MFs, CCs, and BPs enriched with overlapped molecules (DAPs; invasive DEGs) in NF-PitNETs.
| Cluster | Category | ID | Term | Count | % | P Value | Overlapped molecules (DAPs; invasive DEGs) |
|---|---|---|---|---|---|---|---|
| Cluster 1 | Cellular components | GO:0043209 | myelin sheath | 6 | 23.08 | 1.41E-06 | HSPA8, ATP5B, ATP5A1, ALB, SLC25A4, GFAP |
| Biological process | GO:0006754 | ATP biosynthetic process | 4 | 15.38 | 9.15E-06 | ATP5B, ATP5E, ATP5A1, ALDOA | |
| Molecular functions | GO:0016887 | ATPase activity | 5 | 19.23 | 1.41E-04 | HSPA8, ATP5B, ATP5E, ATP5A1, HSPA1A | |
| Molecular functions | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism | 3 | 11.54 | 2.82E-04 | ATP5B, ATP5E, ATP5A1 | |
| Cellular components | GO:0005753 | mitochondrial proton-transporting ATP synthase complex | 3 | 11.54 | 3.44E-04 | ATP5B, ATP5E, ATP5A1 | |
| Biological process | GO:0042776 | mitochondrial ATP synthesis coupled proton transport | 3 | 11.54 | 4.04E-04 | ATP5B, ATP5E, ATP5A1 | |
| Molecular functions | GO:0046961 | proton-transporting ATPase activity, rotational mechanism | 3 | 11.54 | 6.70E-04 | ATP5B, ATP5E, ATP5A1 | |
| Molecular functions | GO:0022857 | transmembrane transporter activity | 3 | 11.54 | 2.37E-03 | ATP5B, ATP5E, ATP5A1 | |
| Pathway | hsa05012 | Parkinson’s disease | 4 | 15.38 | 6.55E-03 | ATP5B, ATP5E, ATP5A1, SLC25A4 | |
| Cellular components | GO:0005759 | mitochondrial matrix | 4 | 15.38 | 8.76E-03 | ATP5B, MTHFD1L, ATP5E, ATP5A1 | |
| Pathway | hsa05010 | Alzheimer’s disease | 4 | 15.38 | 1.04E-02 | ATP5B, ATP5E, ATP5A1, GAPDH | |
| Pathway | hsa05016 | Huntington’s disease | 4 | 15.38 | 1.49E-02 | ATP5B, ATP5E, ATP5A1, SLC25A4 | |
| Cellular components | GO:0005739 | mitochondrion | 6 | 23.08 | 2.73E-02 | ATP5B, MTHFD1L, ATP5A1, PSAP, SLC25A4, HSPA1A | |
| Pathway | hsa00190 | Oxidative phosphorylation | 3 | 11.54 | 5.12E-02 | ATP5B, ATP5E, ATP5A1 | |
| Cluster 2 | Molecular functions | GO:0016887 | ATPase activity | 5 | 19.23 | 1.41E-04 | HSPA8, ATP5B, ATP5E, ATP5A1, HSPA1A |
| Biological process | GO:0046034 | ATP metabolic process | 3 | 11.54 | 9.46E-04 | HSPA8, ATP5B, HSPA1A | |
| Cluster 3 | Biological process | GO:0061621 | canonical glycolysis | 3 | 11.54 | 6.23E-04 | TPI1, ALDOA, GAPDH |
| Biological process | GO:0006096 | glycolytic process | 3 | 11.54 | 1.07E-03 | TPI1, ALDOA, GAPDH | |
| Biological process | GO:0006094 | gluconeogenesis | 3 | 11.54 | 1.79E-03 | TPI1, ALDOA, GAPDH | |
| Pathway | hsa00010 | Glycolysis/Gluconeogenesis | 3 | 11.54 | 1.44E-02 | TPI1, ALDOA, GAPDH | |
| Pathway | hsa01230 | Biosynthesis of amino acids | 3 | 11.54 | 1.65E-02 | TPI1, ALDOA, GAPDH | |
| Pathway | hsa01200 | Carbon metabolism | 3 | 11.54 | 3.81E-02 | TPI1, ALDOA, GAPDH | |
| Cluster 4 | Cellular components | GO:0031012 | extracellular matrix | 4 | 15.38 | 6.67E-03 | HSPA8, ATP5B, ATP5A1, GAPDH |
| Cellular components | GO:0016020 | membrane | 8 | 30.77 | 2.00E-02 | HSPA8, ATP5B, TPM4, MTHFD1L, ATP5A1, RPSA, ALDOA, GAPDH |