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Schematic representation of CYP26A1 affects embryo implantation by regulating uterine macrophage polarization. During the peri-implantation period, CYP26A1 polarizes uterine macrophages towards M1 to provide a certain inflammatory response for embryo implantation. Knockdown of CYP26A1 caused insufficient M1 polarization, resulting in insufficient inflammation and failed embryo implantation. CYP26A1 may regulate the polarization of uterine macrophages to M1 through Stap1 and Slc7a2.
