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. 2021 Oct 12;12:758080. doi: 10.3389/fphar.2021.758080

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Copyright © 2021 Tan, Yu, Liang, Liu, Song, Ge, Fang, Yu, Huang, Jiang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Empagliflozin (EMP) decreased myocardial oxidative stress after cardiac arrest in rats. (A) Representative photographs of 4-hydroxynonenal (4-HNE) and 8-hydroxy-2′-deoxyguanosine (8-OHdG) immunostaining of heart sections obtained 24 h after return of spontaneous circulation (ROSC). Scale bar = 50 μm. (B) Quantification of 4-HNE staining levels from stained heart sections. (C) Quantification of 8-OHdG staining levels from stained heart sections. (D) The relative reactive oxygen species (ROS) levels in heart tissues obtained 24 h ROSC. Data are presented as mean ± SD, n = 6, *p < 0.05, **p < 0.01.