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. 2021 Oct 12;12:758080. doi: 10.3389/fphar.2021.758080

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Copyright © 2021 Tan, Yu, Liang, Liu, Song, Ge, Fang, Yu, Huang, Jiang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of empagliflozin (EMP) on structural integrity of the myocardial mitochondria after cardiac arrest in rats. (A) Representative heart transmission electron microscopy (TEM) images of heart mitochondria at 24 h after return of spontaneous circulation (ROSC). Arrow indicates intermitochondrial junctions (IMJs); Arrowhead indicates lipid droplet. Scale bar = 1 μm. (B) Quantification of heart mitochondrial area by TEM after ROSC. n = 5 and at least 60 mitochondria were counted in each group. (C) Quantification of heart mitochondrial lipid droplet content by TEM after ROSC. n = 5 and 30 photographs were counted in each group. (D) Quantification of heart IMJs by TEM after ROSC. n = 5 and 25 photographs were counted in each group. Data are presented as mean ± SD, *p < 0.05, **p < 0.01.