Table 2.

Univariate and multivariate Cox regression analysis.

Variables	Univariate analysis		Multivariate analysis
	HR (95%CI)	P value	HR (95%CI)	P value
Training set
Age (≥65 vs <65)	1.595 (1.106~2.301)	0.012	1.518 (1.044~2.29)	0.0291
Grade (G3+4 vs G1+2)	2.427 (1.601~3.679)	<0.001	1.264 (0.803~1.990)	0.3109
T stage (T3+4 vs T1+2)	3.108 (2.143~4.508)	<0.001	1.986 (1.028~3.915)	0.0514
Stage (III+IV vs I+II)	4.066 (2.749~6.015)	<0.001	5.384 (2.551~11.369)	<0.001
Risk score (high vs low)	3.678 (2.372~5.703)	<0.001	2.699 (1.716~4.243)	<0.001
Testing set
Age (≥65 vs <65)	2.015 (1.061~3.826)	0.032	2.737 (1.412~5.305)	0.003
Grade (G3+4 vs G1+2)	5.956 (2.311~15.350)	<0.001	2.318 (0.788~6.821)	0.127
T stage (T3+4 vs T1+2)	5.279 (2.543~10.957)	<0.001	2.443 (0.321~18.575)	0.127
Stage (III+IV vs I+II)	5.265 (2.480~1.177)	<0.001	1.510 (0.199~11.461)	0.69
Risk score (high vs low)	10.371 (3.656~29.418)	<0.001	7.991 (2.684~23.786)	<0.001
Total set
Age (≥65 vs <65)	1.674 (1.220~2.298)	0.001	1.734 (1.262~2.383)	0.001
Grade (G3+4 vs G1+2)	2.887 (1.987~4.196)	<0.001	1.766 (1.189~2.622)	0.005
T stage (T3+4 vs T1+2)	3.468 (2.500~4.811	<0.001	1.352 (0.722~2.530	0.346
Stage (III+IV vs I+II)	4.248 (3.012~5.993)	<0.001	3.903 (2.018~7.549)	<0.001
Risk score (high vs low)	3.358 (2.316~4.868)	<0.001	2.424 (1.648~3.563)	<0.001