Table 2.
Clinical characters of the ECMO-supported patients.
| ALL ECMO | Survivors (n = 21) | Non-survivors (n = 53) | P * | |
|---|---|---|---|---|
| Baseline characteristics | ||||
| Sex (male %) | 46 (62.2%) | 14 (66.7%) | 32 (60.4%) | 0.615 |
| Age (years) (M,IQR) | 58 (47–66) | 49 (42–62) | 62 (54–68) | 0.042 |
| Comorbidities | ||||
| Hypertension | 30 (40.5%) | 10 (47.6%) | 20 (37.7%) | 0.435 |
| Diabetes Mellitus | 22 (29.7%) | 7 (33.3%) | 15 (28.3%) | 0.669 |
| Cardiovascular disease | 21 (28.4%) | 4 (19%) | 17 (32.1%) | 0.262 |
| Chronic pulmonary disease | 2 (2.7%) | 0 | 2 (3.8%) | 0.367 |
| Chronic kidney disease | 8 (10.8%) | 3 (14.3%) | 5 (9.4%) | 0.545 |
| Chronic liver disease | 8 (10.8%) | 0 | 8 (15.1%) | 0.059 |
| Digestive disease | 1 (1.4%) | 0 | 1 (1.9%) | 0.526 |
| Cerebral vascular disease | 7 (9.5%) | 2 (9.5%) | 5 (9.4%) | 0.991 |
| Autoimmune and hematopathy | 0 | 0 | 0 | 1.000 |
| Solid tumor | 2 (2.7%) | 0 | 2 (3.8%) | 0.367 |
| Time from onset to admission (days) | 10 (6–17.25) | 12 (5.5–17) | 10 (6–18) | 0.684 |
| SOFA score | 8 (6.75–9) | 9 (7–9.5) | 8 (6–9) | 0.145 |
| Vital signs at admission | ||||
| Heart rate (beats per minute) | 95 ± 23 | 97 ± 22 | 94 ± 23 | 0.631 |
| Temperature (°C) | 36.9 ± 0.9 | 36.9 ± 1.0 | 36.9 ± 0.9 | 0.801 |
| Systolic Blood Pressure (mmHg) | 123 ± 23 | 119 ± 22 | 125 ± 24 | 0.370 |
| Diastolic Blood Pressure (mmHg) | 72 ± 14 | 72 ± 14 | 72 ± 13 | 0.981 |
| Respiratory Rate (beats per minute) | 23 ± 6 | 24 ± 6 | 23 ± 7 | 0.944 |
| Laboratory results at admission | ||||
| White Blood Cell (*109/L) | 11.9 ± 6.2 | 12.7 ± 7.5 | 11.6 ± 5.7 | 0.489 |
| Neutrophil (*109/L) | 10.3 ± 5.98 | 9.92 ± 6.67 | 10.4 ± 5.76 | 0.744 |
| Lymphocyte (cells/uL) | 710 ± 410 | 886 ± 537 | 638 ± 335 | 0.022 |
| Lactate (mmol/L) | 3.33 ± 2.91 | 2.75 ± 1.89 | 3.57 ± 3.26 | 0.542 |
| Platelet (*109/L) | 160 ± 93.7 | 154 ± 61.5 | 162 ± 105.6 | 0.738 |
| Total Bilirubin (umol/L) | 19.8 ± 15.6 | 15.9 ± 10.7 | 21.4 ± 17.1 | 0.257 |
| Creatinine (umol/L) | 77.1 ± 42.5 | 79.3 ± 51.5 | 76.1 ± 38.7 | 0.809 |
| High sensitivity C-reactive protein (mg/L) | 78.6 ± 81 | 65.2 ± 51.2 | 83.5 ± 89.6 | 0.458 |
| Erythrocyte Sedimentation Rate (mm/H) | 60.4 ± 35.5 | 51.3 ± 26.2 | 66.3 ± 40.1 | 0.336 |
| Ferritin (ng/ml) | 1669 ± 1819 | 846.8 ± 1140 | 2901 ± 2095 | 0.077 |
| Procalcitonin (ng/ml) | 3.3 ± 8.4 | 1.81 ± 4.36 | 3.89 ± 9.66 | 0.371 |
| (1,3) - β - D-glucan (pg/ml) | 48.6 ± 33.0 | 62.9 ± 43.9 | 37.9 ± 23.2 | 0.370 |
| Interleukin-6 (pg/ml) | 319.7 ± 705.2 | 468 ± 665 | 237 ± 725 | 0.315 |
| Interleukin-8 (pg/ml) | 44.7 ± 41.7 | 53.2 ± 51.6 | 34 ± 28.4 | 0.529 |
| PaO2 (mmHg) | 89.5 ± 45.7 | 93.9 ± 50.2 | 88.1 ± 44.7 | 0.691 |
| PaCO2 (mmHg) | 49.3 ± 17.1 | 45.3 ± 15.8 | 50.7 ± 17.5 | 0.327 |
| PH value | 7.22 ± 0.59 | 7.06 ± 0.71 | 7.29 ± 0.54 | 0.234 |
| Prognosis related parameters | ||||
| ICU stays (days) | 21 (12.75–33) | 26 (17.5–38) | 18 (10.5–30) | 0.018 |
| Hospital stays (days) | 32 (16–45.5) | 49 (35.5–74) | 29 (13.5–37) | <0.001 |
ECMO, extracorporeal membrane oxygenation; PaO2, partial pressure of oxygen; PaCO2, partial pressure of carbon dioxide; ARDS, acute respiratory distress syndrome; FiO2, fraction of inspired oxygen; ICU, intensive care unit.
*
P-value for the comparison between survivors and non-survivors according to in-hospital mortality.