Figure 4.
Increased galactosylation is associated with improved affinity for FcγRII. The effect of increased and decreased galactose content on binding to FcγRII variants among IgG Fc glycotypes for which other glycan characteristics (e.g., fucosylation, sialylation, bisection) were held constant. Statistically significant differences were tested using a mixed effect model with Tukey’s test of multiple comparisons (*p < 0.05, **p < 0.01, ***p < 0.001). ns, not significant.