Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Oct 12;12:754710. doi: 10.3389/fimmu.2021.754710

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Crowley, Osei-Owusu, Dekkers, Gao, Wuhrer, Magnani, Reimann, Pincus, Vidarsson and Ackerman

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

The fucose effect is generalizable across antibodies but not receptors. (A) Representative sensorgrams showing association and dissociation profiles of RM FcgRIIIa-3 from unmodified and afucosylated forms of a rhesusized version of rituximab. (B) Equilibrium binding affinities of CDR grafted CD20-specific antibodies with rhesus IgG1 Fc domains (left), and a dual variable domain (DVD) bispecific antibody (right) in unmodified and afucosylated forms, and in comparison to an unmodified rhesus IgG1 antibody of a differing specificity (control).