Table 1.

Disturbed miRNAs reported in human AD studies and their relation to Aβ pathways.

miRNA	Sample	Regulation	Relevant pathway	References
miR-15a miR-15 b	Serum	Downregulation	Downregulates BACE1 expression	Satoh et al., 2015; Lang et al., 2016; Li and Wang, 2018
miR-29a	Brain CSF Serum	Down Up Down	BACE1	Hébert et al., 2008; Geekiyanage et al., 2012; Müller et al., 2016
miR-29b	Blood	Down	BACE1	Satoh et al., 2015
miR-29c	Brain	Down	BACE1	Lei et al., 2015
miR-20b	Brain	Down	APP	Nunez-Iglesias et al., 2010
miR-21-5p	Brain	Up	APP	Giuliani et al., 2021
miR-16	CSF	Down	APP	Müller et al., 2014
miR-9	Brain	Down	APP	Hébert et al., 2008
miR-30c	Brain	Down	APP	Cogswell et al., 2008
miR-101a-3p	Brain	Down	APP	Hébert et al., 2008
miR-188	Brain, Serum	Down	APP	Kou et al., 2020
miR-106a	Brain Serum	Down Up	APP	Wang et al., 2011; Cheng et al., 2015
miR-106b	Brain Whole blood	Down Up	APP	Hébert et al., 2008; Cheng et al., 2015
miR-138-5p	Plasma Exosomes	Up	APP	Lugli et al., 2015
miR-138	Brain, CSF	Variant	APP	Boscher et al., 2019
miR-135b	Blood	Down	BACE1	Zhang et al., 2016
miR-124	CSF	Down	APP	Burgos et al., 2014
miR-155	Peripheral Blood mononuclear cells	Upregulated	Inhibits Aβ catabolism	Guedes et al., 2016
miR-34	Peripheral Blood mononuclear cells	Upregulated	Aβ clearance	Basavaraju and de Lencastre, 2016
miR-181b	Peripheral Blood mononuclear cells	Upregulated	Aβ clearance	Kumar and Reddy, 2016
miR-181c	Serum	Downregulated	APP	Geekiyanage et al., 2012
miR-186	Brain	Downregulated	BACE1	Ben Halima et al., 2016
miR-346	Human Neuron Enriched culture	Upregulated	APP	Long et al., 2019
miR-338	Hippocampus	Downregulated	APP	Qian et al., 2019
miR-200	Brain	Upregulated	SIRT1, Aβ accumulation, Apoptosis	Zhang et al., 2017