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. 2021 Oct 12;12:645500. doi: 10.3389/fmicb.2021.645500

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Copyright © 2021 Zhao, Zhou, Dong, Zhang, Xie, Tian and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Lactobacillus reuteri attenuates RTX-induced inflammatory injury. (A) Experimental schedule. (B) Relative abundance of L. reuteri in the intestine of mice detected by qPCR after 5 days of antibiotic administration. (C) Relative abundance of L. reuteri in the intestine detected by qPCR after 5 days of L. reuteri gavage. (D) H&E staining of the ileum and colon (magnification, 40×). (E) Villus length of the ileum. (F) mRNA expression levels of IL-1β, IL-6, IL-10, and claudin in the ileum of mice. Data are expressed as the mean ± SEM. p < 0.05, **p < 0.01, ***p < 0.001, ****P < 0.0001. Con, control; ATB, antibiotic treatment; L. reu, L. reuteri.