Table 1.
The baseline characteristics of enrolled CLM patients.
| All samples | Modeling | Validation | P | ||||
|---|---|---|---|---|---|---|---|
| N | Percentage (%) | N | Percentage (%) | N | Percentage (%) | ||
| Sex | 0.3268 | ||||||
| Female | 6705 | 45.62 | 4443 | 45.34 | 2262 | 46.19 | |
| Male | 7992 | 54.38 | 5357 | 54.66 | 2635 | 53.81 | |
| Tumor site | 0.7332 | ||||||
| Colon, unknown | 21 | 0.14 | 16 | 0.16 | 5 | 0.10 | |
| Left colon | 6135 | 41.74 | 4067 | 41.50 | 2068 | 42.23 | |
| Overlapping lesion | 234 | 1.59 | 154 | 1.57 | 80 | 1.63 | |
| Right colon | 7041 | 47.91 | 4706 | 48.02 | 2335 | 47.68 | |
| Transverse colon | 1266 | 8.61 | 857 | 8.74 | 409 | 8.35 | |
| Histological type | 0.0001 | ||||||
| Adenocarcinoma | 13434 | 91.41 | 9007 | 91.91 | 4427 | 90.40 | |
| Not adenocarcinoma | 1263 | 8.59 | 793 | 8.09 | 470 | 9.60 | |
| Tumor differentiation grade | 0.3698 | ||||||
| II | 9677 | 65.84 | 6470 | 66.02 | 3207 | 65.49 | |
| IV | 738 | 5.02 | 476 | 4.86 | 262 | 5.35 | |
| I | 782 | 5.32 | 507 | 5.17 | 275 | 5.62 | |
| III | 3500 | 23.81 | 2347 | 23.95 | 1153 | 23.55 | |
| T category | 0.6903 | ||||||
| T0 | 3 | 0.02 | 2 | 0.02 | 1 | 0.02 | |
| T1 | 1171 | 7.97 | 785 | 8.01 | 386 | 7.88 | |
| T2 | 354 | 2.41 | 249 | 2.54 | 105 | 2.14 | |
| T3 | 6055 | 41.20 | 4048 | 41.31 | 2007 | 40.98 | |
| T4 | 4626 | 31.48 | 3077 | 31.40 | 1549 | 31.63 | |
| TX | 2488 | 16.93 | 1639 | 16.72 | 849 | 17.34 | |
| N category | 0.9058 | ||||||
| N0 | 3872 | 26.35 | 2580 | 26.33 | 1292 | 26.38 | |
| N1 | 5104 | 34.73 | 3480 | 35.51 | 1696 | 34.63 | |
| N2 | 4740 | 32.25 | 3157 | 32.21 | 1583 | 32.33 | |
| NX | 981 | 6.67 | 655 | 6.68 | 326 | 6.66 | |
| Bone metastasis | 0.2317 | ||||||
| No | 14151 | 96.28 | 9423 | 96.15 | 4728 | 96.55 | |
| Yes | 546 | 3.72 | 377 | 3.85 | 169 | 3.45 | |
| Brain metastasis | 0.9976 | ||||||
| No | 14589 | 99.27 | 9728 | 99.27 | 4861 | 99.26 | |
| Yes | 108 | 0.73 | 72 | 0.73 | 36 | 0.74 | |
| Lung metastasis | 0.6191 | ||||||
| No | 12017 | 81.76 | 8002 | 81.65 | 4015 | 81.99 | |
| Yes | 2680 | 18.24 | 1798 | 18.35 | 882 | 18.01 | |
| Tumor deposit | 0.7094 | ||||||
| No | 6127 | 41.69 | 4068 | 41.51 | 2059 | 42.05 | |
| Unknown | 6607 | 44.95 | 4409 | 44.99 | 2198 | 44.88 | |
| Yes | 1963 | 13.36 | 1323 | 13.50 | 640 | 13.07 | |
| Tumor size | 0.7063 | ||||||
| 0-1cm | 11664 | 79.36 | 7789 | 79.48 | 3875 | 79.13 | |
| 1-5cm | 32 | 0.22 | 23 | 0.23 | 9 | 0.18 | |
| Unknown | 3001 | 20.42 | 1988 | 20.29 | 1013 | 20.69 | |
| Lymph | 0.5509 | ||||||
| No | 13445 | 91.48 | 8948 | 91.31 | 4497 | 91.83 | |
| Unknown | 1232 | 8.38 | 838 | 8.55 | 394 | 8.05 | |
| Yes | 20 | 0.14 | 14 | 0.14 | 6 | 0.12 | |
| CEA | 0.7122 | ||||||
| Negative | 1371 | 9.33 | 905 | 9.23 | 466 | 9.52 | |
| Positive | 8553 | 58.20 | 5725 | 58.42 | 2828 | 57.75 | |
| Unknown | 4773 | 32.48 | 3170 | 32.35 | 1603 | 32.73 | |
| Surgery | 0.8498 | ||||||
| No | 4274 | 29.08 | 2845 | 29.03 | 1429 | 29.18 | |
| Yes | 10423 | 70.92 | 6955 | 70.97 | 3468 | 70.82 | |
| Chemotherapy | 0.7205 | ||||||
| No/Unknown | 4980 | 33.88 | 3311 | 33.79 | 1669 | 34.08 | |
| Yes | 9717 | 66.12 | 6489 | 66.21 | 3228 | 65.92 | |
P-value was adopted on comparation of modeling and verifying dataset. CLM, colon cancer liver metastases; CEA, carcinoembryonic antigen.