TABLE 1.

Summarization of different metal core nanomaterials for different functions in Neurological diagnostics.

Nanomaterial metal core	Type of nanoparticles	Route of administration	Modelin vivo/in Vitro	Mode of action	References
Iron	Ferumoxtran or Ferumoxytol	Intravenous	In vivo	Help in diagnosis of cellular imaging of human ischemic stroke	Yang et al. (2016)
	Endorem	Intravenous or Intracerebral	In vivo	Help in stem cell movement and growth in central nervous system and as contrasting agent for nodal stages. It remains unaffected by metastatic cells	Sonawane et al. (2019)
	Chitosan	Exposition	In vitro	Useful in determination of acetylcholine in synthetic urine	Shcharbina et al. (2013)
Gold	Quercetin	Intravenous	In vivo	It promotes the fusion of autophagosomes and lysosomes. Helps in cleaning Aβ -induced cytotoxic damage	Wong et al. (2012)
	Clioquinol	Intravenous	In vivo	These nanoparticles inhibit β40 plaques, aggregation, cell membrane disruption, and ROS- mediated apoptosis	Kaushik et al. (2018)
Silver	Cellular prion protein 95-110	Incubation/Intravenous	In vivo	Useful in detection of Aβ oligomer with a peptide as the bioreceptor	Liu et al. (2020)
	Gadolinium	Intravenous	In vivo	Used as contrast agent for magnetic resonance imaging	Overk at el., 2014