. 2021 Oct 12;15:746582. doi: 10.3389/fncir.2021.746582

TABLE 2.

Relative changes in expression of Drds/DRDs in PFC throughout postnatal development.

	Receptor / Gene	Rodent								Human / Non-human Primate
		0W	1W	3W	6W	9W	Species	Method	References	S1	S2	S3	S4	S5	S6	S7	Species	Method	References
D1 – like Family	DRD1 / Drd1	+		↔		↔	Rats	RT-qPCR	Araki et al., 2007	+	↓			↑	↔	↓	Humans	In situ	Weickert et al., 2007
				+	↑	↓^*	Rats	In situ	Naneix et al., 2012	+	↑	↑	↑	↔	↓	↓	Humans	RT-qPCR + Microarray	Rothmond et al., 2012
			+	↑^*	↑	↑	Rats	Receptor Autoradiography	Tarazi and Baldessarini, 2000	+	↑	↑	↔	↑	↑^*	↔	Humans	Western Blot	Rothmond et al., 2012
			+	↑	↓		Rats	Receptor Autoradiography	Leslie et al., 1991	+	↔	↑^*	↓	↓	↔	↔	Rhesus Monkeys	Receptor Autoradiography	Lidow and Rakic, 1992
	DRD5 / Drd5	+		↔		↔	Rats	RT-qPCR	Araki et al., 2007	+	↔	↔	↔	↔	↔	↔	Humans	RT-qPCR + Microarray	Rothmond et al., 2012
				+	↑	↓^*	Rats	RT-qPCR	Naneix et al., 2012
D2 – like Family	DRD2 / Drd2	+		↔		↔	Rats	RT-qPCR	Araki et al., 2007	+	↓^*			↑	↓	↑	Humans	In situ	Weickert et al., 2007
	Drd2l			+	↑	↓^*	Rats	RT-qPCR	Naneix et al., 2012	+	↓	↑	↓	↓	↔	↔	Humans	RT-qPCR	Rothmond et al., 2012
	Drd2s			+	↔	↔	Rats	RT-qPCR	Naneix et al., 2012	+	↓	↔	↓^*	↔	↔	↔	Humans	RT-qPCR	Rothmond et al., 2012
			+	↑^*	↑	↑	Rats	Receptor Autoradiography	Tarazi and Baldessarini, 2000	+	↔	↑^*	↓	↔	↔	↔	Rhesus Monkeys	Receptor Autoradiography	Lidow and Rakic, 1992
	DRD3 / Drd3	+		↔		↔	Rats	RT-qPCR	Araki et al., 2007
	DRD4 / Drd4	+		↓^*		↔	Rats	RT-qPCR	Araki et al., 2007	+	↔			↔	↔	↔	Humans	In situ	Weickert et al., 2007
				+	↑	↓^*	Rats	RT-qPCR	Naneix et al., 2012	+	↔	↔	↔	↔	↔	↔	Humans	RT-qPCR	Rothmond et al., 2012
			+	↑^*	↑	↑	Rats	Receptor Autoradiography	Tarazi and Baldessarini, 2000

+ first postnatal stage analyzed & expression detected. ↑ increase; ↓ decrease; ↔ no change in expression compared to previous timepoint; * indicates increase or decrease in expression compared to previous timepoint that were statistically significant; empty cells: no data available. W: Week S: Stage; S1: neonate in humans, 0 month in rhesus monkeys; S2: infant in humans, 1 month in rhesus monkeys; S3: toddler in humans, 2 months in rhesus monkeys; S4: school age in humans, 8 months in rhesus monkeys; S5: adolescent in humans, 12 months in rhesus monkeys; S6: young adult in humans, 36 months in rhesus monkeys; S7: adult in humans, 60 months in rhesus monkeys.