TABLE 2.
Simulation study approximating a linear model for a product of phenotypes using summary statistics. Summaries of errors when approximating slopes, slope standard errors, and the absolute value of the t-statistics for a SNP while adjusting for covariates when using pre-computed summary statistics (PCSS) compared to values obtained when calculating these statistics using individual participant data (IPD).
| Phenotypes | β | SE(β) | |t| | ||||
|---|---|---|---|---|---|---|---|
| IPD Mean | Bias | MSE | Bias | MSE | Bias | MSE | |
| 2 Continuous | 6.09E-03 | 3.72E-04 | 1.43E-05 | 2.39E-06 | 6.58E-11 | 2.33E-03 | 4.13E-01 |
| 2 Binary | 4.13E-01 | 2.56E-02 | 6.74E-03 | 6.58E-05 | 5.50E-07 | 1.65E-01 | 2.16E-01 |
| 3 Continuous | 4.82E+00 | 3.33E-02 | 3.79E-01 | -3.63E-02 | 5.82E-04 | 5.71E-02 | 1.06E-01 |