TABLE 3.
Summary of errors when approximating the linear model: FA Ratio ∼ snp + age + sex using pre-computed summary statistics (PCSS) compared to values obtained when calculating these statistics using individual participant data (IPD). Each fatty acid ratio was modeled across 362,330 SNPs from 1,455 subjects in the Framing Heart Study’s Offspring and Generation-3 cohorts.
| Ratio | β | SE(β) | |t| | ||||
|---|---|---|---|---|---|---|---|
| IPD Mean | Bias | MSE | Bias | MSE | Bias | MSE | |
| PA:POA | 5.58E-02 | 1.49E-02 | 4.18E-02 | −4.80E-02 | 2.08E-04 | 4.38E-03 | 1.45E-02 |
| PA:SA | 5.83E-05 | −2.13E-05 | 3.09E-07 | 1.43E-04 | 1.87E-09 | 4.67E-03 | 8.23E-03 |
| POA:OA | −2.08E-05 | −2.10E-06 | 8.08E-09 | −2.69E-05 | 4.69E-11 | 5.92E-03 | 1.70E-02 |
| SA:OA | −8.15E-05 | −1.19E-05 | 3.62E-07 | −3.33E-05 | 3.36E-10 | 6.86E-03 | 8.21E-03 |
| LA:GLA | −7.35E-02 | 2.03E-02 | 1.32E+00 | −5.10E-01 | 1.95E-02 | 3.11E-02 | 3.17E-02 |
| LA:DGLA | 2.04E-03 | 1.99E-04 | 3.58E-04 | −1.84E-03 | 3.12E-07 | 2.33E-02 | 4.08E-02 |
| GLA:DGLA | 4.58E-05 | 1.04E-05 | 2.64E-07 | −7.62E-06 | 1.13E-10 | 3.36E-02 | 6.50E-02 |
| DGLA:AA | −1.99E-05 | −1.54E-06 | 2.84E-08 | 3.79E-05 | 1.09E-10 | 9.37E-03 | 1.33E-02 |
| AA:DTA | 1.76E-03 | −4.20E-04 | 7.21E-05 | −3.76E-03 | 9.42E-07 | 9.73E-03 | 2.38E-02 |
| EPA:DPA_N3 | 2.29E-04 | −1.38E-05 | 1.31E-06 | −4.04E-04 | 1.02E-08 | 2.34E-02 | 4.72E-02 |
| DTA:DPA_N6 | −1.49E-03 | 1.66E-04 | 7.46E-04 | −1.16E-02 | 8.24E-06 | 4.71E-02 | 1.43E-01 |
| DPA_N3:DHA | −4.12E-04 | 6.03E-05 | 3.45E-06 | −1.52E-04 | 2.53E-09 | 1.56E-02 | 3.75E-02 |
| Overall | −1.30E-03 | 2.93E-03 | 1.14E-01 | −4.80E-02 | 2.12E-02 | 1.79E-02 | 3.77E-02 |