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. 2021 Oct 12;12:740742. doi: 10.3389/fimmu.2021.740742

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Copyright © 2021 Donaubauer, Becker, Weissmann, Fröhlich, Muñoz, Gryc, Denzler, Ott, Fietkau, Gaipl and Frey

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Study design of the prospective IMMO-LDRT01 trial. Examinations are performed before and after the first series of irradiation (tp 1 and 2), before and after the second series of irradiation (tp 3 and 4), as well as for the follow-up appointment three months later (tp 5). The blood drops indicate the time points of the blood withdrawals. Patients fill out questionnaires on life quality and pain levels at the same time points.