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. 2021 Oct 12;12:762012. doi: 10.3389/fgene.2021.762012

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Copyright © 2021 Wilkinson, Starke and Barbee.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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scat interacts genetically with rab11 to control locomotion and muscle integrity. (A, B) Quantification of the number of female flies of the indicated age and genotypes able to cross the 1 cm threshold after climbing for 30 s (n = 20). Here, expression of either a control or scat shRNA transgene (UAS-Luc ^shRNA and UAS-scat ^shRNA) and dominant negative Rab transgene (UAS-rab ^DN) was driven in MNs by C380-Gal4. (C) Representative H&E stained thoracic muscle sections of female flies of the indicated age and genotypes. Sections were obtained in the same region of the thorax and oriented so that the dorsal axis is up. Yellow arrows indicate muscle with signs of atrophy. Statistics: Ordinary one-way ANOVA with Holm-Sidak post-hoc analysis.