Figure 3.

Cytokine changes in CAR-T cell patients treated with prophylactic tocilizumab (n = 13). Scatterplots of cytokine concentrations measured by electrochemiluminescence. Trends generated by locally estimated scatterplot smoothing (LOESS). AUC of cytokine concentration (pg/mL x days) compared with Wilcoxon rank sum test. Blue dots and lines represent patients without CRS, red dots and lines represents patients with CRS. AUC, Area under the curve; CRS, cytokine release syndrome; INFγ, interferon gamma; IL, interleukin; MCP, monocyte chemoattractant protein; MIP, Macrophage inflammatory protein; TNFα, tumor necrosis factor alpha. A. Boxplot of time – based changes in cytokine concentrations with statistically significant differences between patients with CRS (red) and without CRS (blue). Comparisons done with Wilcoxon test.