TABLE 7.
Biological processes that can be associated with atherosclerosis and the associated gene ontology (GO) terms of the overrepresentation analysis (ORA).
| Biological processes related to atherosclerosis | GO Term found in ORA |
| Processes related to the growth and development of endothelial cells which play an important role in the development of atherosclerosis. | • cellular response to vascular endothelial growth factor stimulus |
| • regulation of endothelial cell migration | |
| • vascular endothelial growth factor signaling pathway | |
| • endothelial cell differentiation | |
| • endothelial cell differentiation | |
| • endothelial cell activation | |
| Processes indicating immunological involvement and the presence of messenger substances. | • regulation of leukocyte apoptotic process |
| • leukocyte cell-cell adhesion | |
| • positive regulation of leukocyte chemotaxis | |
| • regulation of leukocyte migration | |
| • regulation of leukocyte differentiation | |
| • regulation of leukocyte apoptotic process | |
| • T cell differentiation | |
| • positive regulation of T cell activation | |
| • T cell differentiation | |
| • alpha-beta T cell activation involved in immune response | |
| • negative regulation of lymphocyte migration | |
| • lymphocyte differentiation | |
| • cytokine secretion | |
| • positive regulation of cytokine production | |
| • cytokine secretion involved in immune response | |
| • cellular response to interleukin-1 | |
| • cellular response to interleukin-6 | |
| • cellular response to transforming growth factor beta stimulus | |
| • cellular response to tumor necrosis factor | |
| • negative regulation of cellular response to growth factor stimulus | |
| Processes that contribute to the remodeling and mineralization and hardening of tissue. | • regulation of ossification |
| • osteoblast differentiation | |
| • regulation of osteoblast differentiation | |
| • regulation of osteoblast proliferation | |
| • negative regulation of osteoblast differentiation | |
| • regulation of biomineralization for plaque calcification | |
| • tissue remodeling | |
| • connective tissue development | |
| • regulation of tissue remodeling | |
| • regulation of muscle tissue development | |
| • tissue homeostasis | |
| Processes related to the blood vessel system in general. | • regulation of vasculature development |
| • cellular response to vascular endothelial growth factor stimulus | |
| • regulation of vasculature development | |
| • vasculogenesis | |
| • coronary vasculature morphogenesis | |
| • regulation of vascular permeability | |
| • artery morphogenesis, artery development | |
| Processes related to the presence of oxidative stress. | • cellular response to oxidative stress |
| • cellular response to hypoxia | |
| • negative regulation of oxidative stress-induced cell death | |
| Processes referred the metabolism of lipids and glucose. | • positive regulation of cholesterol efflux |
| • cholesterol homeostasis | |
| • cholesterol transport regulation of fatty acid beta-oxidation | |
| • fatty acid homeostasis | |
| • response to fatty acid | |
| • regulation of fatty acid metabolic process | |
| • positive regulation of lipid metabolic process | |
| • regulation of lipid storage | |
| • regulation of phospholipid metabolic process | |
| • regulation of lipid kinase activity | |
| • regulation of triglyceride metabolic process | |
| • triglyceride homeostasis | |
| • cellular response to glucose stimulus | |
| • regulation of glucose metabolic process | |
| • cellular glucose homeostasis | |
| • regulation of fat cell differentiation | |
| Processes generally concerned to aging. | • aging • cellular senescence |
| • negative regulation of cell aging | |
| • regulation of cell aging | |
| • regulation of cellular senescence | |
| • cellular senescence |