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. 2021 Oct 5;23:359–369. doi: 10.1016/j.omtm.2021.09.019

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© 2021 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Differentially expressed genes in the subpopulations

(A) Heatmap plots of 161 significantly differentially regulated genes identified for all groups compared (untransduced n = 1,444; CD8-LV [CAR^neg/low] n = 4,216; VSV-LV [CAR^neg/low] n = 1,739; CD8-LV [CAR^high] n = 2,257; VSV-LV [CAR^high] n = 3,084) by the FindAllMarkers function in Seurat (log₂(fold change) ± 0.25, adjusted p value < 0.05). (B) Volcano plots comparing CAR^high, CAR^neg/low, and untransduced (Ut) cells, disregarding the LV used (left) and comparisons of the CD8+ populations in the CD8-LV, VSV-LV, and Ut samples (right). The fold change of CAR is not shown in every plot due to log₂FC > 3. (C) Overlaps of differentially expressed genes identified based on CAR expression levels (left) and vector types (right).