Table 1.

Human dermal fibroblasts reprogrammed to iPSC lines in direct comparative experiments using dbDNA and EBNA1 vectors

Dermal fibroblast source	NCL developmental classification	Passage fibroblast number	Starting material	Time of cryopreservation
Normal	neonate	P32	cryopreserved	<1 year
Normal	juvenile	P16	cryopreserved	<1 year
Normal	juvenile	P9	cryopreserved	<1 year
CLN3-A1	juvenile	P3	fresh	N/A
∗CLN3-A2	juvenile	P3	fresh	N/A
CLN3-B	juvenile	P7	fresh	N/A
CLN3-C	juvenile	P38	cryopreserved	12 years
CLN6-A	juvenile	P8	cryopreserved	15 years
CLN7-A	juvenile	P12	cryopreserved	15 years
CLN7-B	juvenile	P7	cryopreserved	15 years

^∗hDFs refractory to EBNA1-mediated iPSC reprogramming but successful with dbDNA. NCL, Neuronal ceroid lipofuscinosis.