Fig. 5.

Senolytic activity of ES2 in different cell lines, different senescence inducers and different TP53 status. a-h, Line plots of relative viability of seven different cell lines on dividing cells (black) or senescent cells from different senescence inducers: Doxorubicin (red), Dabrafenib (grey), and Palbociclib (blue). Solid lines are best fit polynomial. a-b, Normal epithelial cell line, MCF10a, and fibroblast cell line, IMR90. c-d, Melanoma cell lines A375 and B16F10 (mouse). e, Breast cancer cell line MCF7. f, Colorectal cancer cell line HCT116. g-h, TP53 mutant colorectal cancer cell lines DLD1 and SW480.