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. 2021 Sep 14;12(5):e02388-21. doi: 10.1128/mBio.02388-21

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Copyright © 2021 Vassallo et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 4 — Divergent SitA EDs dictate resistance profiles. (A) Competition indices of chimeras and parent sit(B)AI alleles where target cells were fluorescently labeled (top). The resistance profile of SitA5^Mf1-AI3^Mf1 (chimera C) was determined by its ED, while SitBA3^Mx-AI5^Mf1 (chimera A) was active against both resistant strains. (B) Competition indices as described above for panel A, except that the target strain was ΔsitI3^Mx (ΔsitBAI3^Mx), to the test SitA5^Mf1-AI3^Mx (chimera D), where the SitA5^Mf1 ED determines the resistance profile. SDs from three biological replicates are shown.