FIG 2.

Infection frequency versus cellular half-life. (A) Mixed-effects modeling of total infection frequency per 10⁶ cells versus cellular half-life (days) for all participants and early and late ART treatment groups. (B) Mixed-effects modeling of intact infection frequency per 10⁶ cells versus cellular half-life (days) for all participants. The black line depicts simple regression analysis. P values and R² values can be found for all participants and each ART treatment group. Two R² values are calculated for this model, mR² (marginal) and cR² (conditional), which are similar to a linear regression comparing the relationship between half-life and infection frequency for individual participants or the population as a whole. Marginal R² is calculated using all the data points on the graph regardless of participant, whereas the conditional R² accounts for participant variability. The slopes and 95% CIs are reported for the population-wide trend.