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. 2021 Aug 23;6(1):ysab018. doi: 10.1093/synbio/ysab018

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© The Author(s) 2021. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Contour plots showing how decreasing mutation rates and selection against a transgene influence the longevity of the engineering. For each panel, the starting values of mutation () and selection () yield the half-life value indicated (). The value of given in the figure applies to the lower left corner, a color value of 1 in the key at the right. As the value of mutation or selection is decreased by the factor given on the respective axis (e.g. mutation is and selection is ), the t₅₀ value increases (the engineering persists longer) by the factor indicated in the key. Panels show a nearly 10-fold increase in longevity in the upper right corner, but the separate effects of k_µ and k_s vary across panels as indicated by the contour lines being vertical or horizontal.

Inline graphic — Contour plots showing how decreasing mutation rates and selection against a transgene influence the longevity of the engineering. For each panel, the starting values of mutation () and selection () yield the half-life value indicated (). The value of given in the figure applies to the lower left corner, a color value of 1 in the key at the right. As the value of mutation or selection is decreased by the factor given on the respective axis (e.g. mutation is and selection is ), the t₅₀ value increases (the engineering persists longer) by the factor indicated in the key. Panels show a nearly 10-fold increase in longevity in the upper right corner, but the separate effects of k_µ and k_s vary across panels as indicated by the contour lines being vertical or horizontal.