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. 2021 Aug 23;6(1):ysab018. doi: 10.1093/synbio/ysab018

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© The Author(s) 2021. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Comparisons of parameter estimates with true values using simulated data: effect of carrying capacity. The first row shows cases with transfers every 24 h, for which the population was always well below carrying capacity. On average, the estimates closely match the true values, with a best fit equation of for mutation and for selection. The second row analyzes cases where transfers occur every 72 h, for which the population is mostly growing non-exponentially because of its approach to carrying capacity. The estimates are now substantially biased downward, with a best fit equation of for mutation and for selection. The red line indicates the 1:1 fit expected if the maximum likelihood method worked perfectly, whereas the blue line is the realized fit, with its 95% confidence interval in gray.

Inline graphic — Comparisons of parameter estimates with true values using simulated data: effect of carrying capacity. The first row shows cases with transfers every 24 h, for which the population was always well below carrying capacity. On average, the estimates closely match the true values, with a best fit equation of for mutation and for selection. The second row analyzes cases where transfers occur every 72 h, for which the population is mostly growing non-exponentially because of its approach to carrying capacity. The estimates are now substantially biased downward, with a best fit equation of for mutation and for selection. The red line indicates the 1:1 fit expected if the maximum likelihood method worked perfectly, whereas the blue line is the realized fit, with its 95% confidence interval in gray.