Figure 5.
Forest plots of lipid classes in HCC exosomes vs non-HCC exosomes. Firth logistic regression was performed to assess the associations, (A) between high (Tertile T3) abundance of enriched lipid classes named in Figure 3 and HCC, and (B) between depletion of the lipid classes named in Figure 3 and HCC. OR: odds ratio; AOR: OR adjusted for age, gender and BMI. AcHexSiE: acylGlcSitosterol esters; CerP: ceramides phosphate; CerPE: ceramide phosphoethanolamines; CL: cardiolipins; DLCL: dilysocardiolipins; FA: fatty acids; GD1a: gangliosides; Hex1Cer: hexosylceramides; Hex2Cer: dihexosylceramides; LysoPS: lysophosphatidylserines; OAHFA: (O-acyl)-1-hydroxy fatty acids; PG: phosphatidylglycerols; SPH: sphingosines; ST: sulfatides.