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. 2021 Apr 21;6(2):e00216-21. doi: 10.1128/mSphere.00216-21

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Copyright © 2021 Rogan et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 4 — TRP120 is a predicted Wnt ligand mimic. (A) Protein domain map of TRP120 indicating location of the Wnt SLiM (green) repeated throughout tandem repeat domain (TRD, pink). The N terminus and C terminus are indicated in blue. (B) Protein sequence alignment of TRP120 Wnt SLiM and corresponding homologous sequences in Wnt5a and Wnt5b. Fzd-binding site 1 is boxed in red. A colon indicates similar amino acid substitutions, and an asterisk indicates identical amino acids across the three alignments. (C and D) ISM analysis of TRP120 and XWnt8. (C) Cross-spectrum of TRP120 (accession no. AAO12927.1) and XWnt8 (NP_001081637.1) with ISM frequencies (x axis) plotted against normalized amplitude for each component (y axis). (D) Scanning of the amino acid sequence of XWnt8 along ISM F[0.288] with Fzd-binding site 1 boxed in red.