FIG 1.

Distribution of the sequence variation at a genomic position and CDS level. (A) Variants*, number of genomes with a variant across H37Rv. Mapping of 8,535 genomes against H37Rv demonstrated that 92.2% of H37Rv genomic positions were conserved upon comparison. A small number of positions contained a large amount of genomes containing a variant (1 to 10 genomes had variants in 7.13% of genomic positions of H37Rv, 10 to 100 genomes had variants in 0.49% of H37Rv genomic positions, and 100 to 8,530 genomes had variants in 0.16% of H37Rv genomic positions. (B) Cumulative variants†, cumulative number of variants across the genomes at a CDS level. CDS from 1 to 3906 and their total number of variants across the data set. At a CDS level, all coding sequences have some degree of variation. Mobile elements, repeat regions, transposases, and RNAs were excluded from this analysis.