TABLE 1.
Mobile genetic elements found in Argentinean CC30 MRSA major cladesa
| Genetic determinant | Mobile genetic elements |
|||
|---|---|---|---|---|
| ARG-1 (N = 2) | ARG-2 (N = 5) | ARG-3 (N = 19) | ARG-4 (N = 164) | |
| Plasmid rep and associated genes | rep5, rep16, rep19 | rep5, rep16 | rep5, rep16, rep19 | rep16, rep19, rep21 |
| blaZ (BlaZ type A), arsB, arsC, cadC, cadA, D2JAJ4b | blaZ (BlaZ type C), cadD, cadX | blaZ (BlaZ type C), arsB, arsC, cadD, cadX | blaZ (BlaZ type A), cadD, cadX | |
| Prophage int and associated genes | Sa3int, Sa5int | Sa1int, Sa2int, Sa3int | Sa2int, Sa3int | Sa2int |
| sea, sak, scn, chp | sek, seq, sea, sak, scn, chp, lukS/F-PV (H1a) | sak, scn, chp, lukS/F-PV (H1a) | lukS/F-PV (H2a), sak, scn, chpc | |
| SaPI int and associated genes | intSaPI2, intSaPI4, tst-1 | Not detected | intSaPI2, intSaPI4 | intSaPI3-liked |
| ICEs | ICE6013 | Not detected | Not detected | Not detectede |
a
Table summarizes mobile genetic elements and associated genetic determinants of antimicrobial resistance and virulence. Only genes present in most (>80%) of the strains within each clade are shown.
b
AMR genes blaZ (BlaZ type A), arsB, arsC, cadC, cadA, and D2JAJ4 were present in clade ARG-1 but not found in association with any rep genes on the same contig for this clade.
c
sak, scn, and chp were present in clade ARG-4 without an associated prophage integrase.
d
intSaPI3-like integrase gene shared 96% identity with intSaPI3 from S. aureus COL reference sequence.
e
ICE6013 interspersed in the phylogeny (N = 12).