FIG 6.

Associations between virophages and NCLDVs. (A) Number of associations with virophages is shown for seven NCLDV families and two unclassified groups, “Medusaviruses” and “Pithoviruses.” Associations in the femto-size fraction network are shown in yellow and in the pico-size fraction network are shown in green. The number of positive associations is above the zero axis, and the number of negative associations is below the zero axis. (B) Phylogenetic tree was constructed from 195 environmental virophages and 47 reference MCP sequences. The outside layer indicates three major virophage clades. The inner two layers indicate that the virophage OTUs have at least one association with NCLDVs in femto- or pico-size fraction networks.