FIG 1.

Intratracheal GH therapy does not induce pulmonary damage. Lactate dehydrogenase activity was quantified in bronchoalveolar lavage (BAL) fluid from mouse lungs of immunocompetent BALB/c mice 7 days after intratracheal administration of a single dose of 100 or 500 μg of Sph3_h, PelA_h, or Ega3_h-Pp. Bars represent the means ± standard errors from at least 2 independent experiments with ≥9 mice per group. No significant differences were found between any test condition and the buffer-treated group (P > 0.05) as determined by two-way ANOVA with Dunnett’s multiple-comparison test.