FIG 4.

Single-dose intratracheal GH prophylaxis attenuates fungal virulence in a neutropenic mouse model of pulmonary invasive aspergillosis. Survival of neutropenic mice that were intratracheally infected with 5 × 10⁶ wild-type (WT) A. fumigatus conidia and coadministered with a single dose of 500 μg of Sph3_h (A), PelA_h (B), or Ega3_h-HEK (C). Kaplan-Meier curves represent 3 independent experiments for Sph3_h and 2 independent experiments for PelA_h and Ega3_h-HEK and with ≥10 mice per group. A significant difference is indicated (*, P < 0.01) relative to the buffer-treated WT group as determined by Wilcoxon-rank test.