FIG 1.
Leupeptin can inhibit the catalytic activity of SARS-CoV-2 Mpro in vitro. (A) Chemical structure of leupeptin hemisulfate. (B) Inhibitory curve of leupeptin hemisulfate against SARS-CoV-2 Mpro. (C) Overall structure of SARS-CoV-2 Mpro dimer in complex with leupeptin. (D) Detailed interactions between leupeptin (yellow) and SARS-CoV-2 Mpro. (E) Binding pocket of leupeptin bound to Carica papaya papain protease (PDB accession number 1POP). (F) Binding pocket of leupeptin bound to human calpain-3 protease (PDB accession number 6BKJ).