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. 2021 Sep 28;12(5):e02220-21. doi: 10.1128/mBio.02220-21

FIG 3.

FIG 3

HPLC and HRMS analyses of leupeptin and the QFPD decoction. (A) HPLC chromatogram of the leupeptin reference standard. (B) HPLC chromatogram of the QFPD decoction. The chromatographic peaks in boxes with dotted lines indicate the probable leupeptin substance in the QFPD decoction. (C) MS/MS spectrum of the precursor ion (m/z 427.2969) in the leupeptin reference standard. (D) MS/MS spectrum of the precursor ion (m/z 427.2968) in the QFPD decoction. (E) Proposed fragmentation pathway of leupeptin. The numbers 1 to 11 represent the different fragments of leupeptin.