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. 2021 May 13;11(10):3244–3261. doi: 10.1016/j.apsb.2021.05.005

Figure 6.

Figure 6

The disassembly of FGP for tumor penetration. (A) Illustration of disassembly of FGP to form smaller nanoparticles with acid environment. (B) The release profile of PTX in FGP in different pH (5.0 and 7.4). Data are presented as mean ± SD (n = 3, ∗∗P < 0.01, pH 5.5 vs. pH 7.4). (C) The size distribution of FGP cultured with pH 7.4 and pH 5.0 buffer within 12 h. (D) Tumor penetration of FGP incubated with pH 7.4 and pH 6.0 buffer on 4T1 3D cells (0–60 μm) observed by CLSM z-stack. Scale bar = 500 μm. (E) Dynamic Ce6 fluorescence intensity profiles of section labeled with white arrows in tumor cell spheroids at 50 μm. (F) and (G) The in vivo distribution of Ce6-FGP and FeS-GOx at different time points in 4T1 tumor-bearing mice. (H) Ex vivo fluorescence images and semiquantitative analysis of major organs and tumors at 48 h. Data are presented as mean ± SD (n = 3, ∗∗P < 0.01, FGP vs. FeS-GOx).