Table 5.

Results of age-trajectory group interaction analyses while controlling for age, sex, DNA methylation trajectory group, and dichotomized Glasgow Coma Score

		Interaction Test Statistics
Outcome	n	Est	95% CI	p
NRS-R-3a	49	−0.01	−0.03 to 0.03	0.65
NRS-R-12a	58	−0.03	−0.05 to −0.01	0.004*
		OR	95% CI	P
DRS-3b	112	0.93	0.88 to 0.98	0.01*
DRS-12b	98	0.92	0.87 to 0.97	0.002*
GOS-3c	112	0.96	0.90 to 1.02	0.18
GOS-12c	100	0.93	0.88 to 0.99	0.02*
Death-3c	112	0.96	0.90 to 1.04	0.34
Death-12c	100	0.94	0.87 to 1.01	0.09

Note: n, sample size; Est, Unstandardized estimate from linear regression; OR, Odds Ratio from ordinal and binary logistic regression; 95% CI, 95% Confidence Interval; p, p-value for trajectory group-age interaction term based on an alpha of 0.05; NRS-R-3, Neurobehavioral Rating Scale at 3 months (with square root transformation applied as described in the text); NRS-R-12, Neurobehavioral Rating Scale at 12 months (with square root transformation applied as described in the text); DRS-3; Disability Rating Scale at 3 months (treated as ordinal as described in the text); DRS-12, Disability Rating Scale at 12 months (treated as ordinal as described in the text); GOS-3, Glasgow Outcome Scale at 3 months (treated as binary as described in the text); GOS-12, Glasgow Outcome Scale at 12 months (treated as binary as described in the text); Death-3, Death at 3 months; Death-12, Death at 12 month;

^aLinear regression;

^bOrdinal logistic regression;

^cBinary logistic regression;

^*Suggestive association (p-value <0.05).