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. 2021 Oct 5;12(5):e02424-21. doi: 10.1128/mBio.02424-21

FIG 1.

FIG 1

Malarial disease severity varies widely across eight genetically diverse mouse strains. (A) The eight founder strains (left to right): CAST/EiJ, 129S1/SvImJ, WSB/EiJ, C57BL/6J, NZO/HILtJ, NOD/ShiLtJ, PWK/PhJ, and A/J. For survival, strain colors reflect average survival and parasite load, with dark blue for the most resilient/fewest parasites and dark red for the least resilient (n = 10 for 100% resilient WSB/EiJ, NZO/HILtJ, and 129S1/SvImJ; n = 30 for 73% resilient C57BL/6; n = 32 for 72% resilient CAST/EiJ; n = 15 for 40% resilient NOD/ShiLtJ; n = 15 for 20% resilient A/J; n = 22 for 4.5% resilient PWK/PhJ). DPI, days postinfection. Photo reproduced with permission from Jackson Laboratories. (B) Nine metrics of disease severity across the eight founder strains over the course of acute P. chabaudi infection. Parasitemia = percent parasitized RBCs, parasite density = 106 RBCs per microliter blood, anemia = 106 RBCs per microliter blood). Lines indicate the mean (± SE) of ≥5 mice per strain per day. Z-scores = standard deviations from the means for uninfected C57BL/6 mice.