FIG 3.

Genetic background and Plasmodium infection influence murine plasma metabolomes. (A) Bray-Curtis dissimilarity index was computed on 635 metabolites per sample for infected and uninfected samples. Principal component analysis (PCA) was performed, and sample positions in the first two principal components are displayed. PC1 and PC2 explain 31.2% and 11.5% variation, respectively. Each mouse sample is represented as a number that indicates days postinfection (or mock infection). (B) Disease space loops of RBCs and median PC1 values (derived from Fig. 2 data) plotted against median parasite densities throughout acute P. chabaudi infection. Each line represents the median value for ≥5 mice per strain per day (except final days for nonresilient strains in which <5 individuals remain).