FIG 6.

Mice and humans share plasma metabolic features of Plasmodium infection. A mouse-human correlation network highlights similarity of mouse and human metabolic responses to malaria. Two human metabolic data sets from Malawian cerebral pediatric P. falciparum-infected malaria patients (yellow) (n = 10) and adult Thai severe P. falciparum-infected malaria patients (orange) (n = 10) were analyzed. (A) The 42 metabolites (values Z-scored from uninfected mice or patients) measured in all three data sets were included in a sample-sample interdata set correlation analysis. The resulting network is shown. Each sample is a network node, and edges were drawn between any sample with R² ≥ 0.5. Mouse samples are the median values for each strain (days 8 to 11 or 14 to 17 for WSB/EiJ) postinfection. Each symbol represents the value for a sample from one individual. (B) The same data are used to display for six individual metabolites. M, Malawian; mu, murine; T, Thai.