Table 4.
Overview of toxicity and safety analysis
| n (%) | |
|---|---|
| Number of patients | 159 |
| Number of cycles completed | |
| 0 | 1 (0.6) |
| 1 | 4 (2.5) |
| 2 | 4 (2.5) |
| 3 | 1 (0.6) |
| 4 | 2 (1.3) |
| 5 | 4 (2.5) |
| 6 | 143 (89.9) |
| Reasons for stopping | |
| Toxicity | 10 (62.5) |
| Treatment refusal | 1 (6.3) |
| Intercurrent illness | 3 (18.8) |
| Death | 2 (12.5) |
| Cycles postponed | |
| Number of patients | 21 (13.2) |
| Total cycles postponed | 23 |
| Reason for postponing cycle | |
| Toxicity | 13 (56.5) |
| Intercurrent illness | 4 (17.4) |
| Patient choice | 6 (26.1) |
| Dose reductions | |
| Number of patients | 22 (13.9) |
| Total dose reductions | 23 |
| Reason for dose reduction | |
| Polyneuropathy | 11 (47.8) |
| Neutropenic fever | 6 (26.1) |
| Neutropenia | 2 (8.7) |
| Other | 4 (17.4) |
| Emergency department visits | |
| Number of patients | 47 (29.6) |
| Total number of visits | 74 |
| Hospitalization | |
| Number of patients | 40 (25.2) |
| Total number of hospitalizations | 50 |
| Reason for hospitalization | |
| Toxicity related | 22 (40.7) |
| Cancer related | 9 (16.7) |
| Intercurrent illness | 19 (35.2) |