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. Author manuscript; available in PMC: 2021 Oct 26.
Published in final edited form as: Annu Rev Nutr. 2020 Jun 16;40:273–297. doi: 10.1146/annurev-nutr-013120-041149

Table 2:

Preclinical studies examining the role of caloric restriction on cancer outcome

Cancer (cell line) Animal Route Diet Scheme Effect of diet alone Effect of diet with treatment Ref
B-ALL (8093) C57BL/6J Retroorbital Switch from 60% to 10% fat diet No benefit Improved efficacy of vincristine, but no effect on dexamethasone or L-asparaginase (176)
Breast (4T1) 8-14 week old BALB/c Orthotopic 70% of AL Slowed tumor growth Synergy with irradiation, cisplatin, and docetaxol (148, 160, 161)
Breast (4T1) 12-15 wk old BALB/c mice SQ 50% of AL n.a. No synergy with cisplatin (22)

SQ = subcutaneous