Figure 6. Deep transcriptome profiling of primary and metastatic ID8_VEGF-eLuc ovarian tumors.

RNA expression was evaluated in primary and peritoneal metastatic tumors from mice that underwent orthotopic tumor injection but no cytoreductive surgery, and all samples were obtained when mice reached a terminal endpoint necessitating euthanasia. 160 of 176 KEGG pathways revealed no significant differences (FDR 5%) between primary and metastatic mouse tumor samples. Data obtained from 3 primary mouse tumors and 3 metastatic mouse tumors isolated from the peritoneum. ssGSEA, an extension of GSEA, was used to visualize gene set enrichment scores for each pairing of a sample and gene set.