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. 2021 Oct 12;13:750921. doi: 10.3389/fnagi.2021.750921

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Copyright © 2021 Chen, Chen, Zhang, Jia, Chen, Huang, Xu and Song.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Se-Met increased ATP levels by promoting ATP synthesis. (A) ATP levels in the N2a-SW cell line treated with 10 μM Se-Met (**p < 0.01 vs. the control group, n = 4). (B,C) The enzymatic activity of complex IV (B) and complex V (C) was detected with a Micro Mitochondrial Respiratory Chain Activity Assay Kit (*p < 0.05 vs. the control group, n = 6). (D–F) The expression levels of Cyt c and complex IV in N2a-SW cells (D) and in the cortices of AD mice (F) were detected by western blot analysis. (E–G) Quantitative analysis of the expression levels of Cyt c and complex IV (*p < 0.05 vs. the control group. n = 4; *p < 0.05 vs. AD mice, n = 3 mice).