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Se-Met may attenuate mitochondrial dysfunction by upregulating SELENO O both in vivo and in vitro. (A–C) Expression of SELENO O and TRXR2 in N2a and N2a-SW cells treated with 10 μM Se-Met. (A) The results of quantitative analyses of the expression levels of SELENO O (B) and TRXR2 (C) are shown (*p < 0.05 vs. the control group, n = 3). (D) Expression and quantified levels of SELENO O and TRXR2 in the hippocampi and cortices of 3xTg AD mice (*p < 0.05 vs. AD mice, n = 3 mice).
