Table 3.
Change in diagnosis of functional dyspepsia (FD) and gastroparesis (Gp) at baseline and 48-week follow-up based on solid gastric emptying (GE)
| Total Patients (N=249) | |||
|---|---|---|---|
|
| |||
| 48 Weeks | |||
| Baseline | Gp | FD | |
| Diagnosis | Gp (N=189) | 110 (58%) | 79 (42%) |
| Median at 4-hr GE | Median at 4-hr GE | Median at 4-hr GE | |
| Total patients | 24.0% [16.0, 40.0] | ||
| Gp to Gp | 25.5% [16.5, 42.0] | 23.0% [16.0,38.0] | |
| Gp to FD | 23.0% [14.7, 35.3] | 3.0% [1.9, 5.0] | |
| Diagnosis | FD (N=60) | 22 (37%) | 38 (63%) |
| Median at 4-hr GE | Median at 4-hr GE | Median at 4-hr GE | |
| Total patients | 5.0% [2.5, 8.0] | ||
| FD to FD | 6.0% [2.5, 8.0] | 3.0% [2.0, 5.1] | |
| FD to Gp | 5.0% [2.5, 8.0] | 14.6% [12.6, 21.0] | |
|
| |||
| % Diagnosis Changed | 41% [(79+22)/249] | ||
| % Unchanged | 59% [(110+38)/249] | ||
| P-value† | .005 | ||
Idiopathic (N=182) and diabetic patients (N=67) with baseline and 48-week gastric emptying scintigraphy (GES) test were included; 7 patients with normal emptying and symptoms of gastroparesis not classified as functional dyspepsia (FD) using Rome III were excluded; 34 patients in GpR1, 215 in GpR2.
Presented are the number (percent) of patients in each diagnosis category, and respective medians [IQR] values of each %-gastric retention at 4-hours distribution at baseline and 48-weeks. Gp to Gp: Patients diagnosed with gastroparesis at baseline and who remained in that category at 48-weeks; Gp to FD: Patients diagnosed with gastroparesis at baseline and who were classified as FD (normal emptying) at 48-weeks; FD to FD: Patients diagnosed with normal emptying and FD at baseline and who remained in that category at 48-weeks; FD to Gp: Patients diagnosed with FD at baseline and who were classified as gastroparesis at 48-weeks.
When analyzed separately by etiology subgroup, 75/182 (41%) of the idiopathic subgroup and 26/67 (39%) of the diabetic subgroup changed diagnosis between the baseline and 48-week GES test (P=.40), where P was determined from a logistic regression of the baseline GES diagnosis on the follow-up diagnosis, etiology subgroup, and an interaction term for etiology and follow-up GES diagnosis.
P tests the null hypothesis that the diagnosis changes from baseline to 48-weeks are random. P computed using Fisher’s exact test (2-sided). Bold font denotes a P <.05.