Table 4.

Association Between Safety-Relevant Prescribing Errors and the Use of Amiodarone With DOACs and Major Bleeding.

Variable		Crude OR (95%CI)	P-value	Adjusted ORa (95%CI)	P-value
Type of DOAC	Apixaban	1 (Ref)		1 (Ref)
	Rivaroxaban	2.45 (1.16-5.15)	0.02	2.31 (1.07-5.01)	0.03
	Dabigatran	0.84 (0.27-2.57)	0.76	0.84 (0.27-2.87)	0.84
Concomitant use of Amiodarone		1.85 (0.95-3.61)	0.07	1.70 (0.87-3.32)	0.12
Safety-relevant prescribing errors with DOACs		2.17 (1.15-4.08)	0.02	2.17 (1.14-4.12)	0.02

Abbreviations: DOAC, direct oral anticoagulant; Ref, reference.

^a  Adjusted for age, sex, type of DOAC and concomitant use of amiodarone.